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  • Biosafety laboratory clean engineering design

Biosafety laboratory clean engineering design

Biosafety laboratory: mainly used in microbiology, biomedicine, biochemistry, animal experiments, gene recombination and biological products such as the use of the laboratory collectively known as clean laboratory - biosafety laboratory. The biosafety laboratory consists of the main function laboratory and other laboratories and auxiliary function rooms. Biosafety laboratories must ensure personal safety, environmental safety, waste safety and sample safety, long-term and safe operation, while also providing a comfortable and well-working environment for laboratory staff.
  • Case Introduction

Biosafety laboratory purification works
   Biosafety laboratory: mainly used in microbiology, biomedicine, biochemistry, animal experiments, gene recombination and biological products such as the use of the laboratory collectively known as clean laboratory - biosafety laboratory. The biosafety laboratory consists of the main function laboratory and other laboratories and auxiliary function rooms. Biosafety laboratories must ensure personal safety, environmental safety, waste safety and sample safety, long-term and safe operation, while also providing a comfortable and well-working environment for laboratory staff.

生物洁净实验室设计方案

First, clean laboratory - Biosafety laboratory technical indicators Note:
1), the noise does not include the noise of biological safety cabinets, animal isolators, such as noise including the above equipment, the maximum should not exceed 68dB (A).
2), the minimum negative pressure of the primary biosafety main laboratory relative to the atmosphere shall not be less than -30Pa, and the minimum pressure of the four-stage biosafety main laboratory relative to the atmosphere shall not be less than -50Pa.
3), the minimum negative pressure relative to the atmosphere shall not be less than -50 Pa, and the minimum negative pressure of the animal four-level biosafety main laboratory relative to the atmosphere shall not be less than -60 Pa for the third-level biosafety laboratory of the raised animal.
4), animal clean laboratory - biosafety laboratory parameters should be consistent with GB14925-2001 "laboratory animal environment and facilities" of the relevant requirements.
Second, clean laboratory - Biosafety laboratory program composition:
  
The construction of biosafety laboratory includes: building layout and decoration, air conditioning, water supply and drainage, gas supply, electrical design, centralized control, security, construction technology, testing, training and other aspects, especially for the following Some aspects to be extremely full consideration:
1). Building layout and renovation program: is the basis of clean laboratory - safe operation of biosafety laboratories. Due to the risk of microbial pathogens, it is necessary to prevent the spread of hazardous microorganisms from the outside to comprehensively block the contact pathways between hazardous microorganisms and the external environment, and to avoid the pollution of microorganisms and affect the accuracy of the experimental results. Layout and decoration program. The layout of the laboratory is divided into clean areas, semi-polluted areas and polluted areas according to the safety requirements. It is necessary to set the special channels and set the necessary buffers, and adopt the measures of isolation and secondary isolation to avoid cross Pollution, and fundamentally prevent the spread of hazardous microbes; laboratory decoration using reliable materials, reasonable construction measures to ensure that clean laboratories - biosafety laboratories are always in a relatively sealed environment, to prevent microbial escape, easy to laboratory Clean disinfection, while avoiding external damage to the laboratory environment.
2). Air conditioning system: the key to clean laboratory - safe operation of biosafety laboratories. Because clean laboratories - biosafety laboratories are designed to be hazardous microbes, are harmful to humans, plants, or the environment, and must be kept in a clean laboratory by means of a reasonable air conditioning system - the relative negative pressure of the biosafety laboratory The environment is not destroyed at all times to ensure that hazardous microorganisms in the laboratory can not spread to the external environment。 Air conditioning system must be reliable operation, the use of advanced technology, rational use and conservation of energy and resources to ensure the quality and safety of the environment for the experimental staff to provide the required temperature and humidity to ensure that biological experiments under safe conditions to ensure that the experiment The results are accurate. At the same time it must also control the cleanliness of the laboratory, the new air filter, so that the laboratory to achieve a certain purification requirements. Which is the focus of the exhaust system, to ensure that the laboratory is relatively negative pressure environment and effective filtering indoor air pollution plays an important role.
3). Control system: the entire clean laboratory - biosafety laboratory safe operation of the nerve center. Since the Clean Laboratory - Biosafety Laboratory is designed to be a risky microbiology, it requires real-time monitoring of each laboratory with minimal maintenance personnel, using optimized management and maintenance tools for strict control of pollution Equipment in which the physical environment to ensure that the laboratory is always in the process of running a relatively negative pressure environment to prevent leakage of dangerous microorganisms.
4). Detection program: is a clean laboratory - biosafety laboratory long-term safe operation of the guarantee。 Due to the special nature of the clean laboratory - biosafety laboratory, in addition to strict design, construction, commissioning, in order to ensure its safety, it must be necessary for its engineering testing and strict acceptance, to meet the safety requirements and use requirements Can be put into operation。 In addition, some factors in the use of the process, such as non-professional management and use, efficient filter replacement, etc., will have an impact on the safety of the laboratory, so the use of periodic testing and equally important.
5)。 Training program: As the laboratory laboratory - biosafety laboratory laboratory staff are usually medical experts, the whole system for the laboratory principle is not necessarily very understanding, through training programs, so that all laboratory staff to understand the characteristics of the entire system, master Its operation law, can be found in time for security risks, and timely to make the appropriate emergency response to control the further deterioration of the situation, to reduce the difficulty of follow-up maintenance work is very helpful.

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