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  • Design of Ventilation and Purification Engineering for GMP Vacuum Clean Workshop

Design of Ventilation and Purification Engineering for GMP Vacuum Clean Workshop

With the continuous improvement of China\'s pharmaceutical industry, in accordance with international standardization of quality requirements, in line with the provisions of the GMP clean room is necessary. At present, the use of central air conditioning and three-stage filter is the classic mode of purification technology. This requires a dedicated air conditioning room and about 2m high technical sandwich, the higher technical requirements of the infrastructure, for larger new projects. However, in the pharmaceutical industry, especially in the biological products industry, many production and experimental projects are smaller, many old plants also need to use, due to the structure and cost constraints, the use of the above methods encountered great difficulties.
  • Case Introduction

Design of Ventilation and Purification Engineering for GMP Vacuum Clean Workshop
With the continuous improvement of China's pharmaceutical industry, in accordance with international standardization of quality requirements, in line with the provisions of the GMP clean room is necessary. At present, the use of central air conditioning and three-stage filter is the classic mode of purification technology. This requires a dedicated air conditioning room and about 2m high technical sandwich, the higher technical requirements of the infrastructure, for larger new projects. However, in the pharmaceutical industry, especially in the biological products industry, many production and experimental projects are smaller, many old plants also need to use, due to the structure and cost constraints, the use of the above methods encountered great difficulties.

GMP制药无尘车间通风净化工程

The general height of the old factory in the 3m or so, the size and shape of the actual needs of different large, usually can not be installed in accordance with conventional duct, set the technical sandwich and dedicated air conditioning system. According to the basic principles of air purification, in practice, we explore a very practical clean room technology transformation methods, especially for small and medium-sized clean room technological transformation. Now introduced as follows:
1, structural model
The clean room is built in the old factory building, the room height is 3m, the clean room wall is built with the sandwich color steel plate, the height is about 2.4m, the clean room is the top of the clean room. The clean room is built in the old room, Fan room, about 0。6 m high, which is equipped with a windbox。 All of the fan room enclosed, with inward ventilation in the filter inlet. The fan is installed in the wind box, the lower part of the static pressure box and high efficiency filter. The lower side of the clean room does not return to the primary filter, the outside of the clean room is the return air lane, air return lane connected to each other, which has at least one split split air conditioner. Air conditioning machine can first use the ordinary cabinet split air conditioners, the outlet with a shroud and cold air duct, the other end of the cold air duct installed in the fan room. Under normal circumstances the ordinary air-conditioning fan can be cold air to 15 m away, the basic can meet the general use of small and medium-sized clean room, when the air distance is far, you can install the fan on the cold air pipe to increase the air pressure. It is important to note that the shroud and the cold duct are to be insulated. The thickness of the indoor unit of the general cabinet type air conditioner is generally in the range of 0.25m to 0.35 m (the cooling capacity of the air conditioner is 5000W to 15000W). Considering the width of the shroud, the width of the air return lap can be 0.5 m ~ 0.7 m The When the wall-mounted air-conditioning is used, the width of the return airway can be reduced, and the width of the other return air lanes can be made to be 0.1 m. In this way, the clean room is designed to maximize the use of building space.
2, air circulation mode
Air from the wind into the static pressure box, through the high efficiency filter into the clean room, and then from the return air early filter into the air back to the wind tunnel, part of the return air flow and fresh air from the fresh air filter into the new filter through the efficiency of the filter into Fan room, another part of the return air flow directly into the air conditioning inlet, air cooling through the shroud and cold duct into the fan room. Two parts of the flow in the fan room after mixing, through the wind box on the filter in the efficiency of the fan into the static pressure box, and then by the high efficiency filter into the clean room air circulation system。 From the circulation of the air flow, it is known that a good three-stage filtration condition has been formed. Therefore, the clean room air quality has been a reliable guarantee. On this basis, adjust the structure and layout of the high efficiency filter outlet, together with the corresponding air volume, you can determine the clean room cleanliness and cleanliness to suit different needs. Clean room, on both sides of the local 100 class clean air mainstream area, the rest of the 10,000 clean areas.
3, the main technical characteristics and advantages
(3。1) no main air duct and dedicated air-conditioning room, reduce investment: air flow in the air lane and fan indoor flow, air conditioning is also installed in the air back to the wind, do not need a dedicated air conditioning room, air bag in addition to installation of air conditioning, But also for maintenance and process channels。 Air conditioning air supply is characterized by air pressure at the end of the cold air from the air conditioner sent directly into the fan room, in addition to the cold air duct of their own resistance, there is no other loss of resistance, especially the cold end of the outlet, the wind box to form a certain vacuum Degree, but also help cold air duct to overcome the air resistance. As the cold duct pressure is very low, so the cold air pipe can choose the quality of the lower cost of thin plastic or metal hose. The entire air circulation system in addition to a small amount of auxiliary role in the cold air duct, the other main duct and pipe valve can be omitted。 The entire clean room without main ducts and no dedicated air conditioning room, air flow through the clean room walls and wall panels constitute。 Air conditioning is cheap, reliable, easy to install, so you can save investment and shorten the construction period.
(3.2) air conditioning cooling quickly, energy saving significantly: usually, clean room temperature adjustment is air conditioning by the central air conditioning and then sent to the clean room. The method requires a large number of ducts for long-distance air supply, along the resistance loss and temperature loss caused by a large energy loss. In addition, there are also air-conditioning installed in a dedicated return air straight pipe, and then by the fan and duct air will be sent to the efficient air outlet method, although this method eliminates the central air conditioning, is still need a dedicated fan and duct , The structure is complex, high cost, take up limited space, not easy to repair and operation of air conditioners, fans and ducts caused by energy losses are greater. The program uses the cold air pipe direct air supply way, the air conditioner directly to the cold air directly to the clean air mainstream area, the coldest stroke and the shortest, the most concentrated cold air volume, no special pipe valve, saving investment, installation and more simple. More important is to reduce the resistance of these pipe valve loss and temperature loss, to achieve the purpose of improving efficiency and energy conservation.
(3.3) simple operation, easy maintenance: no special air-conditioned room, do not have to operate, because the wind box and efficient air filter is set according to the need to group, so maintenance and use can also be divided into units.
(3.4) make full use of existing plant, tapping the potential efficiency: the use of existing plant transformation clean room, short construction period, the end of the cost, flexible and practical, is the way to tap the potential efficiency.

From the above scheme, the use of ordinary air conditioners directly to the clean air mainstream area to send cold air method not only save investment, energy conservation, installation and use of convenience, more importantly, the use of mainstream airflow to strengthen the clean area air circulation, to purify the purpose, while And a lot of cold air to the area, so that the temperature quickly reduced。

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